Laminar characteristics of gyrencephaly using high resolution DTI in vivo at 7T
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High Resolution Diffusion Tensor Imaging of the Human Brain at 7T
Magnetic resonance imaging (MRI) at 7T provides higher signal-to-noise ratio (SNR) which enables high-resolution functional and anatomic MRI. There is also an increased demand for high-resolution diffusion tensor imaging (DTI) providing important information about cell physiology and neuronal connectivity. DTI may also profit from higher SNR as diffusion-weighting reduces the signal exponential...
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Introduction: Higher B0 fields are expected to optimize fiber tracking and to increase the signal-to-noise ratio which should lead to higher spatial resolution of DTI [1,2]. However, at high fields B1 inhomogeneities are strong and result in sever distortions and signal voids in DTI. The B1 inhomogeneity results in ill-defined pulse angles that vary considerably over the probe volume. Parallel ...
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INTRODUCTION Diffusion tensor imaging (DTI or HARDI) offers the unique possibility to detect brain microstructure in vivo. However, diffusion weighting requires strong and long gradient pulses that, in addition to strong T2 weighting, reduce the signal significantly to encode the directional information. Therefore, DTI is notoriously SNR hungry and the use of very high field strength has been p...
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Introduction High resolution diffusion tensor imaging (DTI) provides a step towards depicting in vivo smaller fiber tracts such as U-fibers between different cortical and subcortical functional areas. Additionally, smaller pathologies might be detected at an earlier stage [1-4]. Ultra-high fields such as 7T will be advantageous as an initially higher signal-to-noise ratio should allow increased...
متن کاملDiffusion Tensor Characteristics of Gyrencephaly Using High Resolution Diffu- Sion Mri in Vivo at 7 T Accepted Manuscript Diffusion Tensor Characteristics of Gyrencephaly Using High Resolution Diffusion Mri in Vivo at 7t Accepted Manuscript
Gyrification of the human cerebral cortex allows for the surface expansion that accommodates many more cortical neurons in comparison to other mammals. For neuroimaging, however, it forms a feature that complicates analysis. For example, it has long been established that cortical layers do not occupy the same depth in gyri and sulci. Recently, in vivo diffusion imaging has provided insights int...
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